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Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis

✍ Scribed by Cindy Fazenda; Brigite Simões; Robert N. Kelsh; M. Leonor Cancela; Natércia Conceição

Book ID
116508318
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
634 KB
Volume
450
Category
Article
ISSN
0378-1119

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✍ Supaporn Suttamanatwong; Eric D. Jensen; Jody Schilling; Renny T. Franceschi; An 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

## Abstract As part of its catabolic action in bone, parathyroid hormone (PTH) inhibits extracellular matrix mineralization. We previously showed that PTH dose‐dependently induces matrix gla protein (MGP) expression in osteoblasts and this induction is at least partially responsible for PTH‐mediate