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Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response

✍ Scribed by Joo-Hyeon Lee; Dae-Sik Lim

Book ID
111310491
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
193 KB
Volume
273
Category
Article
ISSN
1432-1327

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## Abstract In response to certain types of DNA damage, ataxia telangiectasia and rad3‐related (ATR) phosphorylates checkpoint kinase 1 (CHEK1) resulting in cell cycle arrest and subsequent DNA repair. __ATR__ and __CHEK1__ contain mononucleotide microsatellite repeat regions, which are mutational