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Dual Physiologically Based Pharmacokinetic Model of Liposomal and Nonliposomal Amphotericin B Disposition

✍ Scribed by Leonid Kagan, Pavel Gershkovich, Kishor M. Wasan…

Book ID
120756194
Publisher
Springer US
Year
2013
Tongue
English
Weight
933 KB
Volume
31
Category
Article
ISSN
0724-8741

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The aim of this study was to predict the disposition of midazolam in individual surgical patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes of interindividual variability. Tissue±plasma partition coef®cients (k p ) were scaled from rat to human values by a physi