Dual Palladium- and Proline-Catalyzed Allylic Alkylation of Enolizable Ketones and Aldehydes with Allylic Alcohols
โ Scribed by Usui, Ippei; Schmidt, Stefan; Breit, Bernhard
- Book ID
- 120011925
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 157 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1523-7060
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๐ SIMILAR VOLUMES
Rearrangement of ally1 enol carbonates, prepared from ketones or aldehydes by trapping their enolates with ally1 chloroformate, to give e-ally1 ketones or aldehydes regioselectively is catalyzed by palladium-phosphine complexes under mild condtions.
The generation of quatenary chiral centers through catalytic asymmetric alkylation of ketone enolates has been the subject of investigation in recent years. [1] The palladiumcatalyzed asymmetric allylic alkylation (AAA) of prochiral nucleophiles represents one such strategy for the creation of quate