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Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis

โœ Scribed by Conner, Elizabeth A; Lemmer, Eric R; Omori, Masako; Wirth, Peter J; Factor, Valentina M; Thorgeirsson, Snorri S

Book ID
110064197
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
593 KB
Volume
19
Category
Article
ISSN
0950-9232

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Transgenic mice were constructed using human alpha 1-antitrypsin M and Z genomic clones. Livers of the M lineage mice showed slight cellular pleomorphism and immunohistochemically demonstrable finely granular alpha 1-antitrypsin material in hepatocytes. Z lineage mice with five gene copies per haplo