Dual function inhibitors of relevance to chronic obstructive pulmonary disease

✍ Scribed by Dengfeng Dou; Guijia He; Kevin R. Alliston; William C. Groutas

• Book ID: 104005217
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 602 KB
• Volume: 21
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.12.033

✦ Synopsis

The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual function molecule that sequentially inhibits HNE and caspase-1 in a time-dependent manner is reported.