Dual function inhibitors of relevance to
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Dengfeng Dou; Guijia He; Kevin R. Alliston; William C. Groutas
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Article
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2011
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Elsevier Science
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English
โ 602 KB
The general strategy and rationale underlying the design of COPD therapeutics that possess protease inhibitory activity and are also capable of releasing a species that attenuates inflammation by inhibiting caspase-1, are described. The synthesis and in vitro biochemical evaluation of a dual functio