Dual androgen-response elements mediate androgen regulation of MMP-2 expression in prostate cancer cells
β Scribed by Ben-Yi Li; Xin-Bo Liao; Atsuya Fujito; J. Brantley Thrasher; Fang-Yun Shen; Ping-Yi Xu
- Book ID
- 111357386
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 643 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1008-682X
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## Abstract Activation of PKCΞ΄ in androgenβdependent LNCaP prostate cancer cells leads to apoptosis via the activation of p38 MAPK and JNK cascades. We have recently shown that treatment of LNCaP cells with phorbol 12βmyristate 13βacetate (PMA) leads to a PKCΞ΄βmediated autocrine release of death fa
Quantitative expression profile of androgen-regulated genes (ARGs) was evaluated in the hormone-responsive prostate cancer cell line LNCaP by serial analysis of gene expression (SAGE). A total of 83,489 SAGE tags representing 23,448 known genes or expressed sequence tags (ESTs) and 1,655 potentially