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Drugging the p53 pathway: understanding the route to clinical efficacy

โœ Scribed by Khoo, Kian Hoe; Verma, Chandra S.; Lane, David P.

Book ID
121834261
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
516 KB
Volume
13
Category
Article
ISSN
1474-1776

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Background: Gene therapy of human tumors with adenovirus vectors presents a clinical research challenge and a potential opportunity in cancer therapy. One of the research challenges is that endpoints like tumor reduction, time to recurrence, and survival do not provide information about whether a po