Drug Target miRNA: Methods and Protocols

✍ Scribed by Marco F. Schmidt (eds.)

Publisher: Humana Press
Year: 2017
Tongue: English
Leaves: 318
Series: Methods in Molecular Biology 1517
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents’ limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery.

✦ Table of Contents

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Front Matter....Pages 3-22
Front Matter....Pages 23-23
Back Matter....Pages 25-50
....Pages 51-69

✦ Subjects

Pharmacology/Toxicology

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