Drug release from an erodible drug-polyelectrolyte complex

✍ Scribed by Cherng-Ju Kim; Yvonne N. Nujoma

• Book ID: 103075046
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 388 KB
• Volume: 31
• Category: Article
• ISSN: 0014-3057
• DOI: 10.1016/0014-3057(95)00053-4

✦ Synopsis

The release of oxprenolol from drug-PMMA/MANa gel beads via the erosion process was investigated. A synchronized constant gel thickness was observed because the rates of swelling and erosion are equal, resulting in non-Fickian release kinetics. The release of oxprenolol HCl was influenced to a smaller extent by the pH and buffer concentration of the dissolution medium. At pH 5.9 in l/l5 M buffer, erosion did not occur due to the lower pH condition in comparison with the pK, of PMMA/MAA. As a result, the drug release was severely retarded.