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Drug release characteristics of multi-reservoir type microspheres with poly(dl-lactide-co-glycolide) and poly(dl-lactide)

✍ Scribed by Akihiro Matsumoto; Yasuhisa Matsukawa; Takehiko Suzuki; Hiroyuki Yoshino

Book ID
113690918
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
551 KB
Volume
106
Category
Article
ISSN
0168-3659

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✍ Young-Il Jeong; Hee-Sam Na; Jae-Woon Nah; Hyun-Chul Lee πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 158 KB

In this study, we created ciprofloxacin.HCl (CIP)-encapsulated poly(DL-lactide-co-glycolide) (PLGA) microspheres by the solvent evaporation method. Their antibacterial activity was evaluated with pathogenic microorganisms in vitro and in vivo. Since the half-life of CIP in the blood stream is short,