Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

✍ Scribed by Haiyung Cheng; William J. Jusko

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 292 KB
• Volume: 12
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510120108

✦ Synopsis

Equations for the mean number of cycles through the peripheral system ( R ) and the mean transit time through the central compartment (MTT,) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CL,), dose, and area under the plasma concentration-time curve (AUC). The MTT, is a function of the central volume of distribution, CL,, dose, and AUC. The application of the proposed calculations of R and MTT, was illustrated by computer simulations.

KEY WORDS Drug redistribution Mean number of cycles through the peripheral system Mean transit time Concentration-average clearance Disposition decomposition analysis