Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines
✍ Scribed by M. Teresa Donato; M. José Gómez-Lechón; José V. Castell
- Book ID
- 112799989
- Publisher
- Society for In Vitro Biology
- Year
- 1990
- Tongue
- English
- Weight
- 998 KB
- Volume
- 26
- Category
- Article
- ISSN
- 1475-2689
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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev