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Drug Interactions between HIV Protease Inhibitors and Acid-Reducing Agents

✍ Scribed by Dr Ronald W. Falcon, Thomas N. Kakuda

Book ID
119926845
Publisher
Springer International Publishing AG
Year
2008
Tongue
English
Weight
167 KB
Volume
47
Category
Article
ISSN
0312-5963

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✍ Hirokazu Yamaji; Yasuhiro Matsumura; Yukako Yoshikawa; Kanji Takada πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 171 KB πŸ‘ 2 views

The interactions of four HIV-protease inhibitors, ritonavir (RIT), saquinavir (SAQ), indinavir (IND) and nelfinavir (NEL), were examined by in vitro metabolic studies using rat liver microsomal fractions. The substrate concentrations employed were 0.75 12 mM, and the inhibitor concentrations were 2.