𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Drug-induced inhibition of proteoglycanase activity in the hulth–telhag model

✍ Scribed by Dr. Kenneth K. Ishizue; Dr. Michael G. Ehrlich; Henry J. Mankin

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
539 KB
Volume
7
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis

Evidence has accumulated that there are increased degradative enzymes in osteoarthritis responsible for joint destruction. These enzymes are metal-dependent, and inhibited by EDTA. EDTA was administered intraarticularly to rabbits in an experimental model of osteoarthritis. There was a 25% reduction in neutral proteoglycanase activity and 75% of the animals had a reduction in the severity of the arthritis as measured on a histologichistochemical grading system. It is suggested that future chemotherapeutic studies on arthritis might focus on enzyme inhibition.

📜 SIMILAR VOLUMES

Inhibition of the nucleoside transporter
Inhibition of the nucleoside transporter inhibits disease progression in the rat adjuvant-induced arthritis model
✍ Hidekazu Kosaka; Masahiro Koshiba; Takashi Nakazawa; Goh Tsuji; Jun Saegusa; Sug 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

## Abstract We investigated the in vivo effects of the nucleoside transporter inhibitor nitrobenzylmercaptopurine (NBMPR) on rat adjuvant‐induced arthritis. This agent inhibits uptake of adenosine into cells, presumably leading to increased levels of extracellular adenosine. Arthritis was induced i

2-deoxyglucose inhibits chemotheapeutic
2-deoxyglucose inhibits chemotheapeutic drug-induced apoptosis in human monocytic leukemia U937 cells ith inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation
✍ Naomi Haga; Mikihiko Naito; Hiroyuki Seimiya; Akihiro Tomida; Jian Dong; Takashi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB 👁 2 views

Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind

Ethanol inhibits prolactin-induced activ
Ethanol inhibits prolactin-induced activation of the JAK/STAT pathway in cultured astrocytes
✍ William J. DeVito; Scott Stone 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB 👁 2 views

Alcohol consumption has multiple effects in the central nervous system (CNS). Whereas, alcohol is an immunosuppressive drug the effect of alcohol on the neuroimmune system, remains unclear. In cultured astrocytes, prolactin (PRL) induces mitogenesis and the expression of inflammatory cytokines, incl