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Drug impurity profiling strategies

✍ Scribed by S. Görög; M. Babják; G. Balogh; J. Brlik; A. Csehi; F. Dravecz; M. Gasdag; P. Horváth; A. Laukó; K. Varga

Book ID
117224068
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
776 KB
Volume
44
Category
Article
ISSN
0039-9140

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Besides several known impurities in cimetidine, two additional compounds at levels below 0.1% were detected by ion-pair reversed-phase high-performance liquid chromatography (HPLC). The impurities were isolated from crude cimetidine using normal-phase preparative HPLC. 1H and 13C NMR and mass spectr