𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Drug encapsulation using supercritical fluid extraction of emulsions

✍ Scribed by P. Chattopadhyay; R. Huff; B.Y. Shekunov


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
297 KB
Volume
95
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis


The current work was aimed at evaluating a new method, supercritical fluid extraction of emulsions (SFEE), for the production of composite (e.g., polymer-drug) micro-and nanoparticles, intended for application in sustained-release drug delivery formulations. Using the proposed method, composite particles were obtained, both in a continuous or batch manner by supercritical carbon dioxide extraction of oil-in-water (o/w) emulsions. Model drugs indomethacin and ketoprofen and biodegradable polymers poly(lactic/glycolic) acid and Eudragit RS were used in order to demonstrate the effectiveness of the SFEE process for producing these particles. Stable aqueous suspensions of composite micro and nanoparticles, having sizes ranging between 0.1 and 2 mm were consistently obtained. Emulsion droplet diameter was found to be the major size control parameter. Other parameters investigated included polymer and drug concentrations in solvent and emulsion solvent fraction. The residual solvent content in the particle suspension obtained was consistently below 50 ppm. Standard dissolution tests were used to observe the sustained release phenomenon of the composite particles. The dissolution profile was characterized in terms of the intrinsic dissolution kinetic coefficients taking into account the specific surface area and solubility of the particles. It was observed that the kinetic coefficient parameter for encapsulated drugs was reduced by 2-4 orders of magnitude when compared to the unprocessed drug particles.


πŸ“œ SIMILAR VOLUMES


Extraction of paeonol from Jisheng Shenq
✍ Ben Liu; Yiling Chang; Hailiang Jiang; Bo Shen πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 132 KB

## Abstract Supercritical carbon dioxide with or without methanol and 95% ethanol modifiers was used to extract paeonol from the pills of __Jisheng Shenqi Wan__ and high‐performance liquid chromatography (HPLC) was used to analyze the extract. The effect of temperature and pressure on the yield of

Extraction of magnolol from Magnolia off
✍ J. R. Dean; B. Liu; R. Price πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 98 KB πŸ‘ 1 views

Supercritical carbon dioxide, with and without a methanol modifier, has been compared with a new portable cold solvent extraction technique, employing phytosols A, B and D for the extraction of magnolol from Magnolia officinalis. High performance liquid chromatography (HPLC) was used to analyse the

Application of supercritical fluid extra
✍ Heaton, Darren M. ;Bartle, Keith D. ;Rayner, Christopher M. ;Clifford, Anthony A πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 475 KB

## Abstract The supercritical fluid extraction (SFE) of taxicin from the dried needles of the English yew tree, __Taxus baccata__ is described. Analysis by supercritical fluid chromatography (SFC) and proton NMR spectroscopy was used to confirm identity and purity. The extraction efficiency of SFE