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Application of supercritical fluid extraction and supercritical fluid chromatography to the production of taxanes as anti-cancer drugs

✍ Scribed by Heaton, Darren M. ;Bartle, Keith D. ;Rayner, Christopher M. ;Clifford, Anthony A.

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
475 KB
Volume
16
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

The supercritical fluid extraction (SFE) of taxicin from the dried needles of the English yew tree, Taxus baccata is described. Analysis by supercritical fluid chromatography (SFC) and proton NMR spectroscopy was used to confirm identity and purity. The extraction efficiency of SFE is comparable with that obtained using liquid solvents. Such taxanes may be used semi‐synthetically to prepare potential anti‐cancer drugs.

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