𝔖 Bobbio Scriptorium
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Drug allergy to the β-lactam antibiotics clavulanic acid and amoxicillin

✍ Scribed by Y. D. Cahen; B. Wüthrich

Book ID
110884930
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
217 KB
Volume
52
Category
Article
ISSN
0105-4538

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Theoretical Calculations of β-Lactam Ant
Theoretical Calculations of β-Lactam Antibiotics. Part VI. AM1 calculations of alkaline hydrolysis of clavulanic acid
✍ Juan Frau; Josefa Donoso; Francisco Muñoz; Francisco García Blanco 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 German ⚖ 989 KB

The gas-phase basic hydrolysis of clavulanic acid (a) was studied by using the AM1 semi-empirical method. The results obtained show that the hydroxyethylidene side chain at C(2) is pivotal to the stability of the different reaction products involved. The products with an open oxazolidine ring are mo