DRD2 Ser311/Cys311 polymorphism in schizophrenia
β Scribed by S. Nanko; M. Hattori; Xy Dai; R. Fukuda; H. Kazamatsuri; MargaretA. Piggott; ElaineK. Perry; lanG. McKeith; Elizabeth Marshall; RobertH. Perry; P. Asherson; N. Williams; E. Roberts; M. McGuffin; M. Owen; S. Shaikh; D. Collier; M. Arranz; D. Ball; M. Gill; R. Kerwin
- Book ID
- 118554117
- Publisher
- The Lancet
- Year
- 1994
- Tongue
- English
- Weight
- 479 KB
- Volume
- 343
- Category
- Article
- ISSN
- 0140-6736
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π SIMILAR VOLUMES
As part of the European Multicentre Association Study of Schizophrenia (EMASS), we studied polymorphisms in the dopamine DRD2 and DRD3 receptor genes. The EMASS collaboration was established to create a large, statistically powerful sample of schizophrenic patients and controls from different Europe
A mutation in the DRDS receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations. The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional. W e report the results of screening U
## Abstract Previously we derived independent estimates of the effect of the dopamine D2 receptor (__DRD2__) Ser311Cys polymorphism on risk for schizophrenia using fixedβ and randomβeffects metaβanalyses. Both analyses identified a significant association between the Cys allele and schizophrenia, b