✦ LIBER ✦

Dopamine DRD2/Cys311 is not associated with chronic schizophrenia

✍ Scribed by Crawford, Fiona ;Hoyne, Jonathan ;Cai, Xingang ;Osborne, Aaron ;Poston, Devin ;Zaglul, Jose ;Dajani, Nabil ;Walsh, Shirley ;Bradley, Richard ;Solomon, Richard ;Mullan, Michael

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 219 KB
Volume: 67
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960920)67:5<483::aid-ajmg8>3.0.co;2-l

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✦ Synopsis

A mutation in the DRDS receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations. The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional. W e report the results of screening US Caucasian schizophrenic and nonschizophrenic populations. We detected the occurrence of the DRDS Cys3ll variant in both schizophrenics and controls. Our data demonstrates no significant difference between the frequency of Cys311 in Caucasian schizophrenic and non-schizophrenic populations, indicating no association with schizophrenia.

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