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Drastic Effect of Germline TP53 Missense Mutations in Li-Fraumeni Patients

✍ Scribed by Zerdoumi, Yasmine; Aury-Landas, Juliette; Bonaïti-Pellié, Catherine; Derambure, Céline; Sesboüé, Richard; Renaux-Petel, Mariette; Frebourg, Thierry; Bougeard, Gaëlle; Flaman, Jean-Michel

Book ID
119960203
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
427 KB
Volume
34
Category
Article
ISSN
1059-7794

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Association of germline or somatic TP53
Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome
✍ Waka Sugawara; Yasuhito Arai; Fumio Kasai; Yuiko Fujiwara; Masayuki Haruta; Rie 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 700 KB

## Abstract Germline __TP53__ mutations are found in Li‐Fraumeni syndrome (LFS) patients, predisposed to soft tissue sarcoma and other malignancies. The mutations and succeeding genetic events are thought to cause LFS‐associated cancer, whose genetic alterations have rarely been investigated. Here,