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DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

✍ Scribed by Hahn, S. A.; Schutte, M.; Hoque, A. T. M. S.; Moskaluk, C. A.; da Costa, L. T.; Rozenblum, E.; Weinstein, C. L.; Fischer, A.; Yeo, C. J.; Hruban, R. H.; Kern, S. E.

Book ID: 121155663
Publisher: American Association for the Advancement of Science
Year: 1996
Tongue: English
Weight: 661 KB
Volume: 271
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.271.5247.350

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## Abstract Allelic imbalance on chromosome arm 22q has been detected in 50–70% of ovarian cancers, suggesting the presence of a tumor‐suppressor gene on this chromosome arm that is involved in ovarian carcinogenesis. Recently, we isolated a candidate tumor‐suppressor gene, __MYO18B__, at 22q12.1,