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Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21

✍ Scribed by Vincent M. Aita; Xiao Huan Liang; V.V.V.S. Murty; David L. Pincus; Weiping Yu; Eftihia Cayanis; Sergei Kalachikov; T.Conrad Gilliam; Beth Levine

Book ID: 115614780
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 188 KB
Volume: 59
Category: Article
ISSN: 0888-7543
DOI: 10.1006/geno.1999.5851

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## Abstract Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors. The __BLU__ gene, located at 3p21.3, has recently been identified as a