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Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

✍ Scribed by Susana Cardoso; Renato X. Santos; Cristina Carvalho; Sónia Correia; Gonçalo C. Pereira; Susana S. Pereira; Paulo J. Oliveira; Maria S. Santos; Teresa Proença; Paula I. Moreira


Book ID
113630668
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
601 KB
Volume
45
Category
Article
ISSN
0891-5849

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Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc