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Closure of VDAC causes oxidative stress and accelerates the Ca2+-induced mitochondrial permeability transition in rat liver mitochondria

โœ Scribed by Andrey Tikunov; C. Bryce Johnson; Peter Pediaditakis; Nikolai Markevich; Jeffrey M. Macdonald; John J. Lemasters; Ekhson Holmuhamedov


Book ID
116178577
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
572 KB
Volume
495
Category
Article
ISSN
0003-9861

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Contribution of increased mitochondrial
โœ Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 356 KB

Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc