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Doxorubicin Conjugates of Monoclonal Antibodies to Hepatoma-Associated Antigens

โœ Scribed by Daniel Shouval, Ruth Adler, Jack R. Wands, Esther Hurwitz, Kurt J. Isselbacher and Michael Sela

Book ID
123636146
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
908 KB
Volume
85
Category
Article
ISSN
0027-8424

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Specific targeting of adriamycin conjuga
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โœ Ruth Adler; Esther Hurwitz; Jack R. Wands; Michael Sela; Daniel Shouval ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 741 KB

Doxorubicin (adriamycin), once considered the treatment of choice for hepatocellular carcinoma (HCC), is known to cause cardiotoxicity and myelotoxicity. To reduce the systemic toxicity of adriamycin by direct delivery of the drug to the tumor site, we established a panel of monoclonal antibodies (M