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Downregulation of the CD95 receptor and defect CD40-mediated signal transduction in B-chronic lymphocytic leukemia cells

โœ Scribed by N. Laytragoon-Lewin; E. Duhony; X.-F. Bai; H. Mellstedt


Book ID
114792468
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
533 KB
Volume
61
Category
Article
ISSN
0902-4441

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B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of mature-appearing clonal B cells exhibiting coexpression of CD5 and CD23. In addition to the accumulation of neoplastic B cells, numerous T-cell abnormalities also occur in B-CLL patients. In this study, the presence,