Defective expression and modulation of B7-2/CD86 on B cells in B cell chronic lymphocytic leukemia
β Scribed by Zhen-sheng Dai; Qin-fen Chen; Hong-zhou Lu; Yi Xie
- Book ID
- 107618771
- Publisher
- Carden Jennings Publishing
- Year
- 2009
- Tongue
- English
- Weight
- 337 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0925-5710
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Analysis of peripheral blood (>85% CD19+/CD5+ B) lymphocytes, obtained from 44 patients affected by B chronic lymphoid leukemia (B-CLL), showed that surface TNF-related apoptosis inducing ligand (TRAIL) was expressed in all samples and at higher levels with respect to unfractionated lymphocytes and
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 Ψ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a