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Downregulation of SAMHD1 Expression Correlates with Promoter DNA Methylation in Sézary Syndrome Patients

✍ Scribed by de Silva, Suresh; Wang, Feifei; Hake, Timothy S; Porcu, Pierluigi; Wong, Henry K; Wu, Li

Book ID
121273552
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
202 KB
Volume
134
Category
Article
ISSN
0022-202X

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## Abstract Promoter‐region DNA methylation inhibits transcription. A two‐stage SENCAR (__sen__sitive to mouse __car__cinogenesis) mouse skin carcinogenicity model was used to examine gene‐specific changes in methylation during skin tumor promotion. Analysis was performed on 7,12‐dimethylbenz[a]ant