Downregulation of apoptosis in the target tissue prevents low-dose streptozotocin-induced autoimmune diabetes
β Scribed by E.P.K. Mensah-Brown; S. Stosic Grujicic; D. Maksimovic; A. Jasima; A. Shahin; M.L. Lukic
- Book ID
- 117325416
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 269 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0161-5890
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π SIMILAR VOLUMES
The imbalance of Th1/Th2 subsets is an important pathogenic mechanism for insulin-dependent diabetes mellitus (IDDM). Calcitonin gene-related peptide (CGRP) has been found to play important roles in the regulation of T lymphocytes. We hypothesize that exogenous CGRP administration during insulitis m
In mice, an experimental autoimmune diabetes can be induced by multiple injections with low doses of streptozotocin. Since different mouse strains show a varying susceptibility towards this treatment, we have examined whether the experimental autoimmune diabetes is under the genetic control of the m