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Down-Regulation of the Endoplasmic Reticulum Chaperone GRP78/BiP by Vomitoxin (Deoxynivalenol)

✍ Scribed by Gi-Hyeok Yang; Shiguang Li; James J. Pestka

Book ID
112267041
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
213 KB
Volume
162
Category
Article
ISSN
0041-008X

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Versipelostatin, a novel GRP78/Bip molec
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✍ Hae-Ryong Park; Kazuo Furihata; Yoichi Hayakawa; Kazuo Shin-ya πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 115 KB

We discovered a novel down-regulator of grp78 gene expression designated as versipelostatin from the culture broth of Streptomyces versipellis 4083-SVS6. Its structure was determined to be a macrocyclic compound consisting of an a-acyltetronic acid and sugar moieties.