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Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells

✍ Scribed by HUIQIU CAO; YULIN HU; PENG WANG; JIANHUA ZHOU; ZHENGHAO DENG; JIFANG WEN

Book ID
114787254
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
424 KB
Volume
120
Category
Article
ISSN
0365-5555

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## Abstract Cisplatin is a chemotherapeutic agent that is widely used to treat cancers such as head and neck squamous cell carcinoma (HNSCC). Previously, we have reported that cisplatin induced an early caspase‐dependent apoptosis (8 hr) in a HNSCC cell, HN4. In this study, we examined a late caspa