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Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance

✍ Scribed by Fabienne Niederer; Michelle Trenkmann; Caroline Ospelt; Emmanuel Karouzakis; Michel Neidhart; Joanna Stanczyk; Christoph Kolling; Renate E. Gay; Michael Detmar; Steffen Gay; Astrid Jüngel; Diego Kyburz

Book ID
112002639
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
345 KB
Volume
64
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Hyperplasia of fibroblast‐like synoviocytes (FLS) contributes to chronic inflammation and joint destruction in rheumatoid arthritis (RA). FLICE‐inhibitory protein (FLIP) is an antiapoptotic protein that might prevent apoptotic elimination of FLS in response to death ligand