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Down-Regulation of Mcl-1 by Inhibition of the PI3-K/Akt Pathway Is Required for Cell Shrinkage-Dependent Cell Death

✍ Scribed by Takashi Araki; Matsuhiko Hayashi; Naohide Watanabe; Hirotaka Kanuka; Jun Yoshino; Masayuki Miura; Takao Saruta

Book ID
115589389
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
245 KB
Volume
290
Category
Article
ISSN
0006-291X

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In vitro experiments have shown that the establishment of cell-cell contacts in intestinal epithelial cell cultures is a critical step in initiating ERK inhibition, cell cycle arrest, and induction of the differentiation process. Herein, we determined the mechanisms through which E-cadherin-mediated