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Down-regulation of manganese-superoxide dismutase gene expression in idiopathic nephrotic syndrome

✍ Scribed by Toshimasa Yoshioka; Noriko Iwamoto; Yuri Tsunoda; Chieko Higuchi; Hiroshi Kawaguchi; Katsumi Ito

Book ID
117165877
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
712 KB
Volume
130
Category
Article
ISSN
1097-6833

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Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme that reduces superoxide anion to hydrogen peroxide in cell mitochondria. MnSOD is overexpressed in normal aging brain and in various central nervous system disorders; however, the mechanisms mediating the upregulation of MnSOD under the