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Diethyldithiocarbamate Treatment Up Regulates Manganese Superoxide Dismutase Gene Expression in Rat Liver

✍ Scribed by Silvia Borrello; Maria Emilia De Leo; Matteo Landriscina; Bernardetta Palazzotti; Tommaso Galeotti


Book ID
115578207
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
345 KB
Volume
220
Category
Article
ISSN
0006-291X

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Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme that reduces superoxide anion to hydrogen peroxide in cell mitochondria. MnSOD is overexpressed in normal aging brain and in various central nervous system disorders; however, the mechanisms mediating the upregulation of MnSOD under the