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Down-regulation of Epidermal Growth Factor Receptors in the Differentiation of 3T3-L1 Fibroblasts to Fat Cells

✍ Scribed by HARRY T. HAIGLER; RICHARD K. GORDON; PETER K. CHIANG


Book ID
118723427
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
101 KB
Volume
463
Category
Article
ISSN
0890-6564

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Incubation of Swiss mouse 3T3 cells at 37Β°C with bovine brain-derived growth factor (BDGF) decreased the cell surface '251-EGF binding activity of these cells by 70-80%. This down-modulation of the EGF receptor by BDGF was time, temperature, and dose dependent. Scatchard plot analysis indicated that