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Down-regulation of DDAH2 and eNOS induces endothelial dysfunction in sinoaortic-denervated rats

✍ Scribed by Jinzhong Feng; Hede Luo; Yihua Qiu; Wei Zhou; Feng Yu; Feng Wu

Book ID: 113589325
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 695 KB
Volume: 661
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2011.04.041

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## Abstract In vivo administration of the mitochondrial inhibitor 3‐nitropropionic acid (3‐NP) produces striatal pathology mimicking Huntington's disease (HD). However, the mechanisms of cell death induced by metabolic impairment are not fully understood. Previous studies showed that 3‐NP triggered