๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Down-regulation of collagen XII in transformed mesenchymal cells

โœ Scribed by Martin U. Kopp; Luigi P. Croci; Beat Trueb

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
849 KB
Volume
60
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Collagen XI1 is a complex multidomain protein associated with the surface of interstitial collagen fibrils. This protein is produced in large amounts by fibroblasts cultivated in vitro. However, it is completely absent from cells transformed by the oncogene v-myc or v-src and from cells derived from a methylcholanthrene-induced fibrosarcoma. Since all these cells lack any mRNA for collagen XII, it seems likely that the synthesis is blocked at the transcriptional level. Experiments with a temperature-sensitive mutant of Rous sarcoma virus demonstrated that a single oncogene product is sufficient to inhibit the synthesis. A reduction in the expression of collagen XI1 might have profound effects on the stability of the extracellular matrix of transformed cells.

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