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Down-Regulation of CGRP-Mediated cAMP Accumulation in ras-Transformed 3T3 Fibroblasts

✍ Scribed by NAMBI AIYAR; MICHAEL R. MATTERN; GLENN A. HOFMANN; RICHARD M. EDWARDS; PONNAL NAMBI

Book ID: 119867024
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 160 KB
Volume: 657
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.1992.tb22796.x

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## Abstract Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras‐mediated transformation. We identified a novel potent inhibitor of Ras‐mediated morphologi