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Altered properties of cAMP-dependent protein kinase in H-ras-transformed NIH3T3 cells

✍ Scribed by Takaki Hiwasa; Shigeru Sakiyama

Book ID
117056888
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
418 KB
Volume
139
Category
Article
ISSN
0006-291X

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We examined the effects of the introduction of H-ras oncogene into murine cell line NIH3T3 on growth inhibition by topoisomerase-I (topo-I) inhibitors. The H-ras-transformed cells (pT22-3) showed approximately I 2-fold increased sensitivity to a novel topo-l inhibitor, NB-506 [6-N-formylamino-I2,I3d