Doubly adaptive biased coin designs with delayed responses
β Scribed by Feifang Hu; Li-Xin Zhang; Siu H. Cheung; Wai S. Chan
- Book ID
- 102102464
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- French
- Weight
- 192 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0319-5724
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Randomized optimum designs of biased-coin type are compared with other strategies for the sequential allocation of two or more treatments in a clinical trial. The emphasis is on the variance of estimated treatment contrasts. This variance, which depends on the design strategy employed, may be interp
## Abstract We consider a response adaptive design of clinical trials with a varianceβpenalized criterion. It is shown that this criterion evaluates the performance of a response adaptive design based on both the number of patients assigned to the better treatment and the power of the statistical t