Double stereodifferentiating Lewis acid-promoted (Mukaiyama) aldol bond constructions.
โ Scribed by Evans, David A.; Yang, Michael G.; Dart, Michael J.; Duffy, Joseph L.; Kim, Annette S.
- Book ID
- 126274445
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 271 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Asymmetric aldol reactions in aqueous media have been realized by using zinc-based chiral Lewis acids. The aldol products have been obtained with high yield, diastereocontrol and a good level of enantioselectivity. The reactivity of both acetophenone and propiophenone enol ether surrogates was teste
Lewis acid promoted C-glycosidation reactions of activated glycals with chiral (E)-crotylsilanes were found to be highly regio-and diastereoselective. The reactions of chiral silane reagents proceed with the formation of a new C-C bond at C6 of the pyran ring with concomitant migration of C5-C6 doub