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Asymmetric Mukaiyama-Aldol Reaction in Aqueous Media Promoted by Zinc-Based Chiral Lewis Acids

✍ Scribed by Jacek Mlynarski; Joanna Jankowska

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 76 KB
Volume: 347
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200404314

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✦ Synopsis

Asymmetric aldol reactions in aqueous media have been realized by using zinc-based chiral Lewis acids. The aldol products have been obtained with high yield, diastereocontrol and a good level of enantioselectivity. The reactivity of both acetophenone and propiophenone enol ether surrogates was tested with a range of aldehydes.

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