Aqueous Asymmetric Mukaiyama Aldol React
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Hui-Jing Li; Hong-Yu Tian; Yan-Chao Wu; Yong-Jun Chen; Li Liu; Dong Wang; Chao-J
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Article
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2005
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John Wiley and Sons
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English
⚖ 251 KB
👁 1 views
## Abstract The combination of Ga(OTf)~3~ with chiral semi‐crown ligands (**1a**–**e**) generates highly effective chiral gallium Lewis acid catalysts for aqueous asymmetric aldol reactions of aromatic silyl enol ethers with aldehydes. A ligand‐acceleration effect was observed. Water is essential f