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Double modulation of 5-fluorouracil in advanced colorectal cancer with low-dose interferon-α2b and folinic acid. The “GISCAD” experience

✍ Scribed by Labianca, R.; Giaccon, G.; Barni, S.; Ambrosini, G.; Iirillo, A.; Fiorentini, G.; Duro, M.; Piazza, E.; Oliani, C.; Pancera, G.; Cascinu, S.; Martignoni, G.; Zaniboni, A.; Dallavalle, G.; Luporini, G.

Book ID
122086292
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
779 KB
Volume
30
Category
Article
ISSN
0959-8049

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Randomized phase III Study of 5-fluorour
Randomized phase III Study of 5-fluorouracil plus high dose folinic acid versus 5-fluorouracil plus folinic acid plus methyl-lomustine for patients with advanced colorectal cancer
✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized