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Dose-response and biased set study of an amphetamine and a barbiturate

✍ Scribed by Neil Mc K. Agnew; Carole H. Ernest

Book ID
104758414
Publisher
Springer
Year
1971
Tongue
English
Weight
795 KB
Volume
19
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Three dosage levels of barbiturate and three of amphetamine were compared with a placebo, all under three set conditions (neutral, stimulant and sedative). Drug reactions were assessed by performance measures and by self-rating scales administered at a series of standard times following the drug administration in order to provide drug-time-response patterns.

The self-rating scales yielded clear dosage-time-response curves for both drugs at all dosage levels. There was no systematic evidence of set or drug-by-set-effects. Research strategies in human drug studies are discussed.

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