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A study of tobacco carcinogenesis II. Dose-response studies

✍ Scribed by Ernest L. Wynder; Patricia Kopf; Helen Ziegler

Publisher
John Wiley and Sons
Year
1957
Tongue
English
Weight
638 KB
Volume
10
Category
Article
ISSN
0008-543X

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πŸ“œ SIMILAR VOLUMES

A study of tobacco carcinogenesis IV. Di
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lNCE different types of tobacco are used S in the manufacture of smoking products, it was thought pertinent to compare these tobacco types with respect to their biological activity in the experimental animal. T o do this four types of cigarettes, composed of Burley, Virginia, Maryland, and Turkish t

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## Abstract Sprague‐Dawley rats and NMRI mice were treated with urethane in the drinking water for 2 years. In both species the daily doses were: 100, 500, 2,500, and 12,500 ΞΌg/kg. The frequency of animals with malignancies increased steadily with increasing doses, beginning from 500 ΞΌg/kg/day for